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Dr. Hafron's Interview with WDIV - Advanced Prostate Cancer

Urology Specialties, Treatments & Technology
MIU Advanced Prostate Cancer Clinic

The MIU Advanced Prostate Cancer Clinic provides the highest and most advanced quality of care, for patients with advanced prostate cancer.   Our comprehensive approach combines the latest treatment options available, with a team of dedicated and experienced clinicians that specializes in advanced prostate cancer.  Specifically, we focus on the early identification of disease progression in patients with advanced disease ensuring patients receive the best therapy at the appropriate time.  Our rigorous approach is known to improve the survival and quality of life of our patients.

In recent years, there have been multiple advancements in treatment for this patient population. The most common treatments for advanced prostate cancer are:

Hormone Therapy:

Also called androgen deprivation therapy (ADT) lowers androgen levels.   Androgens, including testosterone, stimulate prostate cancer cell growth. Lowering androgen to levels that simulate castration can shrink or slow cancer cell growth.

Most men with advanced prostate cancer eventually stop responding to hormone therapy.  When this happens and the cancer continues to grow, despite hormone therapy, it is referred to as castration-resistant prostate cancer. Your MIU Advanced Prostate Clinic doctor may prescribe advanced hormonal oral medications such as ZYTIGA® (abiraterone acetate) or XTANDI® (enzalutamide) to treat castration-resistant prostate cancer.

Learn More About Zytiga Here!

Learn More About Xtandi Here!


PROVENGE® (sipuleucel-T) is an immunotherapy that works by boosting your own immune system to fight your advanced prostate cancer.  PROVENGE® is a personalized treatment that is made from your own immune cells.  After your immune cells are collected, they are ‘activated’ to recognize and attack your prostate cancer cells, once they are returned to your body through a brief infusion process. 

National cancer guidelines recommend PROVENGE® as a first line treatment option for advanced prostate cancer for men with few or no cancer-related symptoms.

Learn More About Provenge Here!

If you would like more information regarding Provenge therapy please contact Pamela Jones:


XOFIGO® (Radium -223), is approved by the FDA for use in men who have advanced prostate cancer that has spread to the bones, and are having pain.  It works by binding to minerals within bones to deliver radiation directly to bone tumors.  It improves survival and can relieve pain.  Palliative Radiation therapy delivered externally by machine technology, is another option of radiotherapy.

Learn More About Xofigo Here!


Another treatment option when hormone therapy stops working.  Proven chemotherapy medications for advanced prostate cancer include:

TAXOTERE® (docetaxel) – The first chemotherapy drug proven to help patients with advanced prostate cancer to live longer.  Often used with a steroid, TAXOTERE® works by preventing cancer cells from dividing and growing.

JEVTANA® (carbazitaxel) is often prescribed when TAXOTERE® is no longer effective.  It is used with the steroid, prednisone, to treat advanced prostate cancer that has progressed, and is resistant to other anti-cancer medicines.

Learn More About Taxotere Here!

Learn More About Jevtana Here!

In cases where prognosis may be poor, due to progression or ‘high risk’ disease, and no longer responding to standard treatment, a clinical trial may be offered by our Prostate Cancer Specialists, through our Research Department.

Bone Health:

Bone health and maintenance of bone strength are important components of comprehensive cancer care in both early and late stages of prostate cancer. Michigan Institute of Urology is committed to offering their patients the most comprehensive prostate cancer care.

Loss of bone mass is common as men age, and can be worse in men with prostate cancer. Cells that help rebuild bone do not get replaced at the same rate, resulting in bones that become thin and porous (full of tiny holes). This condition, called osteoporosis, is the most common type of bone disease. People with osteoporosis are more likely to suffer fractures and painful disabilities because of weakened, fragile bones.  Additionally, men with prostate cancer can lose bone strength from their treatments or from the spread of cancer into the bones.

In order to improve your bone health, your MIU physician will refer you to a nurse that specializes in bone health.  During your visit, the nurse will assess the strength of your bones and your risk of complications associated with your bone health. During your visit, the nurse will discuss a variety of ways to reduce your risk of fractures and improve your overall bone health.

Protection From Common Side Effects Of Radiation Therapy:

SpaceOAR® hydrogel, a new device that works to protect prostate cancer patients from common side effects of radiation therapy. As the first and only prostate cancer spacing device to receive Food and Drug Administration (FDA) clearance, SpaceOAR hydrogel is placed between the prostate and rectum, protecting the rectum and surrounding tissue from high-dose radiation exposure.

Learn More about SpaceOAR® here.

Contact Us:

MIU’s Prostate Cancer Specialists will discuss options with you and plan a treatment that works best for your disease and lifestyle.

If you would like to schedule an appointment in our Advanced Prostate Cancer Clinic, with one of our Prostate Cancer Specialists, please contact Pamela Jones at or 248-740-0670.

General Adult Urology
Urology is the medical specialty concerned with diseases of the urinary tract in men and women, and diseases of the genital tract in men. There are about 9,500 practicing urologists in the United States. The typical education track for a urologist is 4 years of medical school, 1 or 2 years of general surgery training, and 3 or 4 years of residency in urology. Some urologists continue their education after residency in a focused area of subspecialty- a fellowship.

Fellowship training in urology can be accomplished in urologic oncology, pediatrics, voiding dysfunction, laparoscopy/endourology, sexual medicine, pelvic reconstructive surgery, clinical research and male infertility. The specialty combines medical and surgical training, and encompasses a wide variety of clinical problems in men and women of all ages. For more about the specialty and the requirements for certification see The American Board of Urology.

Patient Information for Adult Urology

How Does The Urinary System Work?

Your body takes nutrients from food and uses them to maintain all bodily functions including energy and self-repair. After your body has taken what it needs from the food, waste products are left behind in the blood and in the bowel. The urinary system works with the lungs, skin, and intestines—all of which also excrete wastes—to keep the chemicals and water in your body balanced. Adults eliminate about a quart and a half of urine each day. The amount depends on many factors, especially the amounts of fluid and food a person consumes and how much fluid is lost through sweat and breathing. Certain types of medications can also affect the amount of urine eliminated.

The urinary system removes a type of waste called urea from your blood. Urea is produced when foods containing protein, such as meat, poultry, and certain vegetables, are broken down in the body. Urea is carried in the bloodstream to the kidneys.

What Causes Problems In The Urinary System?

Problems in the urinary system can be caused by aging, illness, or injury. As you get older, changes in the kidneys’ structure cause them to lose some of their ability to remove wastes from the blood. Also, the muscles in your ureters, bladder, and urethra tend to lose some of their strength. You may have more urinary infections because the bladder muscles do not tighten enough to empty your bladder completely. A decrease in strength of muscles of the sphincters and the pelvis can also cause incontinence, the unwanted leakage of urine. Illness or injury can also prevent the kidneys from filtering the blood completely or block the passage of urine.

We have provided you with a wealth of information on General Urology conditions, treatments and technology below. To learn more about your office visit, what to expect and what to bring to your appointment please click here.

Male Infertility
Infertility is the inability to conceive after at least one year of unprotected intercourse. Since most people are able to conceive within this time, physicians recommend that couples unable to do so be assessed for fertility problems.

In men, hormone disorders, illness, reproductive anatomy trauma and obstruction, and sexual dysfunction can temporarily or permanently affect sperm and prevent conception. Some disorders become more difficult to treat the longer they persist without treatment.

Patient Information for Male Infertility

According to the National Institutes of Health, male infertility is involved in approximately 40% of the 2.6 million infertile married couples in the United States. One-half of these men experience irreversible infertility and cannot father children, and a small number of these cases are caused by a treatable medical condition.

We have provided you with a wealth of information on Male Infertility conditions, treatments and technology below. To learn more about your office visit, what to expect and what to bring to your appointment please click here.

Male Sexual Dysfunction
A sexual problem, or sexual dysfunction, refers to a problem during any phase of the sexual response cycle that prevents the individual or couple from experiencing satisfaction from the sexual activity.

Researchers say that sexual dysfunction is common 31% in men and 43% in women report some degree of difficulty. This is a topic that many people are not comfortable to discuss. Most cases of sexual dysfunction are treatable, so it is very important to share your concerns with your partner and doctor or urologist.

What causes sexual problems?

Sexual dysfunction can be a result of a physical or psychological problem.

Physical causes

Many physical and/or medical conditions can cause problems with sexual function. These conditions include diabetes, heart and vascular (blood vessel) disease, neurological disorders, hormonal imbalances, chronic diseases such as kidney or liver failure, and alcoholism and drug abuse. In addition, the side effects of certain medications, including some antidepressant drugs, can affect sexual desire and function.

Psychological causes

These include work-related stress and anxiety, concern about sexual performance, marital or relationship problems, depression, feelings of guilt, and the effects of a past sexual trauma.

Patient Information for Male Sexual Dysfunction

We have provided you with a wealth of information on Male Sexual Dysfunction conditions, treatments and technology below.To learn more about your office visit, what to expect and what to bring to your appointment please click here.

Urologic Oncology
Urologic Oncology is a subspecialty of Urology. Cancer can develop in any organ of the urinary system and the male reproductive system. As with other forms of cancer, the earlier a urological cancer is detected, the greater the chance of successful treatment, that is, removing it before it becomes aggressive and spreads.

Not all abnormal masses of cells are cancerous. A biopsy -by removing a small sample of tissue so the cells can be examined with a microscope will determine if a tumor is cancerous (malignant) or non-cancerous (benign).

It’s important to know the symptoms of urological cancer and see your doctor as soon as possible if you have any of them. Of course, most symptoms have several possible causes. Only a medical examination can determine if the actual cause is cancer or another condition. Seeing your doctor can ease your fears.

The Michigan Institute of Urology are committed to providing outstanding care by offering the latest and most effective therapies in a compassionate setting.

Patient Information for Urologic Oncology

Thousands of men and women are diagnosed each year with cancer of the bladder, kidney and the prostate. New breakthroughs in cancer care, treatment options and ongoing reasearch for potential cures of urologic malignancies give new hope for patients from all walks of life.

We have provided you with a wealth of information on Urologic Oncology conditions, treatments and technology below.To learn more about your office visit, what to expect and what to bring to your appointment please click here.

Neurologic Urology
Neurologic Urology is a subspecialty of Urology. Neurologic Urology focuses on disorders or conditions of the bladder, urinary tract, kidneys and genitalia related to neurological disorders and spinal injuries. For example, patients with neurological conditions such as Parkinson’s disease or multiple sclerosis may experience problems such as overactive bladder or sexual dysfunction. Neurologic Urology involves diagnosing the source of the condition or problem and treating it through surgery, medication, or behavioral changes.

Patient Information for Neurologic Urology

We have provided you with a wealth of information on Neuro-Urology conditions, treatments and technology below. To learn more about your office visit, what to expect and what to bring to your appointment please click here.

MIU Men's Health Foundation
Since its formation in 2009, MIU Men’s Health Foundation has become a leader in men’s health advocacy both locally and nationally. The Foundation’s local work collecting data about men’s health has attracted national attention to propel investment in healthcare strategies for men across the country.

MIU Men’s Health Foundation is dedicated to supporting men’s survivorship, embracing their dedication to choosing to know about their health and their choice to “Fight Like A Man” to protect it. To achieve these goals, MIU Men’s Health Foundation introduced Fight Like A Man International, Blue Monday, Blue Fund, and it’s signature events, Run for the Ribbon and The Men’s Health Event. In addition, since its inception, MIU Men’s Health Foundation has provided over $140,000 in grants to organizations dedicated to men’s health initiatives. Through the addition of a Clinical Cancer Care Coordinator, we are now a direct resource for prostate cancer patients as they navigate through treatment. The Foundation also introduced the Prostate Cancer Survivorship Series, quarterly events for prostate cancer survivors and their families to share stories and moments of survivorship.

Visit the foundation by clicking here!